BACE1 (isoform C) polyclonal antibody
产品名称： BACE1 (isoform C) polyclonal antibody
英文名称： BACE1 (isoform C) polyclonal antibody
产品编号： PAB4691
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of BACE1 (isoform C).
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region of human BACE1 (isoform C).
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-200)
Immunohistochemistry (1:50-100)
Flow cytometry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.
Christensen MA, Zhou W, Qing H, Lehman A, Philipsen S, Song W.Mol Cell Biol. 2004 Jan;24(2):865-74.
- 2.
- The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.
Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B.J Biol Chem. 2003 Dec 5;278(49):48713-9. Epub 2003 Sep 24.
- 3.
- Characterization of the ectodomain shedding of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
Hussain I, Hawkins J, Shikotra A, Riddell DR, Faller A, Dingwall C.J Biol Chem. 2003 Sep 19;278(38):36264-8. Epub 2003 Jul 11.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of BACE1 (isoform C) polyclonal antibody (Cat # PAB4691) in NCI-H460 cell lysate (35 ug/lane). BACE1C (arrow) was detected using the purified polyclonal antibody.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with BACE1 (isoform C) polyclonal antibody (Cat # PAB4691) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 23621
- Protein Accession#:
- P56817-3
- Gene Name:
- BACE1
- Gene Alias:
- ASP2,BACE,FLJ90568,HSPC104,KIAA1149
- Gene Description:
- beta-site APP-cleaving enzyme 1
- Omim ID:
- 604252
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
- Other Designations:
- APP beta-secretase,aspartyl protease 2,beta-secretase,beta-site amyloid beta A4 precursor protein-cleaving enzyme,beta-site amyloid precursor protein cleaving enzyme,memapsin-2,membrane-associated aspartic protease 2,transmembrane aspartic proteinase Asp2
- Interactome
- Gene Pathway