DPABH-01424 detects endogenous levels of IRS1 only when phosphorylated at S312.May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. *   http://www.creative-diagnostics.com/Anti-IRS1-PAb-199546-489.htm